Modular nanoparticles for creation of ‘smart’ adaptable vaccines
Active immunization (vaccination) depends on an efficient means to activate the immune response against specific pathogens. Pathogens are continually emerging and changing; therefore, there is a need for flexible vaccine delivery systems. Our laboratory has focused on the development of such vaccine systems using antigen-loaded nanoparticles constructed from biodegradable and biocompatible, FDA-approved polymer and incorporating adjuvants for immune stimulation. Unlike traditional adjuvants, our nanoparticle design can allow for targeted delivery of antigen to antigen-presenting cells, protection during transit and sustained release of antigen during vaccination.
Fahmy TM, Mellman I, Caplan M, Saltzman WM, Design opportunities and challenges for Nanoparticle Vaccines. Nanomedicine. 2008 Jun;3(3):343-55.